Glucomannan Konjac & Chromium Complex | High Dietary Fibre | Suppresses Appetite and Promotes Weight Loss | 90 Capsules

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Possible glucomannan benefits include helping weight loss, reducing blood sugar, and reducing cholesterol. While the evidence suggests it works, the dietary fibre has not yet received full medical approval. More research is needed. It is no secret that being overweight can be bad for your health. High levels of body fat are linked to a range of unpleasant conditions from heart disease to some cancers. At the same time, many people believe that we are programmed to retain excess calories in case of lean times ahead. No wonder that losing weight is so difficult for much of the population, despite the importance of doing so. No studies of Lipozene have been published as per 2018. The only question to ask is ‘what does Glucomannan do?’ Harmless and reasonably useless, it made a splash in the early part of the 2000’s without landing its proponent in very much legal trouble, and it remains fairly well known today, partly thanks to a seemingly perpetual ad campaign that never uses the word ‘glucomannan.’One placebo-controlled trial involved 176 healthy overweight participants who were split into four different groups; participants in group one were given a daily glucomannan supplement, while those in group two received glucomannan with guar gum; those in group three received glucomannan with guar gum and alginate and those in group four received a daily placebo. All participants followed a 1200 calorie controlled diet for 5 weeks.

Glucomannan is a source of fibre taken from the root of the Konjac plant (Latin name Amorphophallus konjac). It has been found that up to 40% of the weight of the Konjac root consists of this impressive polysaccharide. the beneficial effect is obtained with a daily intake of 3 g of glucomannan in three doses of 1 g each, together with 1-2 glasses of water, before meals and in the context of an energy-restricted diet. Collectively, these data outline the intrinsic impacts of glucomannan on tumor cell apoptosis, proliferation, and metastatic activity, which are the essential basis for its anti-tumor function. To a large extent, such effects are attributed to glucomannan-mediated inhibition of the PI3K/AKT signaling pathway. As a result, increased ratio of pro-apoptotic to anti-apoptotic gene expression undermines the immortality of tumor cells, while the reduced level of CCR7 and CXCR4 compromises their migratory capability. Glucomannan Enhances Anti-Oxidative Activity and Induces Autophagy in Tumor Cells

Studies proved that bile acid is in close relationship with the carcinogenesis process ( Mizutani and Mitsuoka, 1982). It could promote gastrointestinal (GI) inflammation ( Jia et al., 2018) and change the composition of normal gut microbiota, by means of which bile acid becomes a risk factor during tumor formation ( Jia et al., 2018). Administration of Konjac glucomannan was found to increase the fecal output of total bile acids in rats ( Ikegami et al., 1984; Wu and Chen, 2011b). What’s more, Konjac glucomannan significantly decreases secondary bile acid level in human subjects ( Wu et al., 2011a). Therefore, the reduction of bile acids would be another functional aspect of glucomannan supplementation. On the other hand, the probiotics, mainly lactobacilli and bifidobacteria, are indicated for their anti-colorectal cancer function through binding to the mutagens, inhibiting the activity of β-glucuronidase, and reducing the level of carcinogenic secondary bile acid ( Wu et al., 2011a; Chong, 2013). In various studies, glucomannan is shown to enhance the content of probiotics and its metabolic products, short-chain fatty acids (SCFAs), in feces ( Mizutani and Mitsuoka, 1982; Ikegami et al., 1984; Yeh et al., 2007; Wu and Chen, 2011b; Wu et al., 2011a; Chong, 2013; Wu et al., 2014; Quezada et al., 2017). SCFAs promote the functionality of normal intestinal epithelium and the gut integrity ( Chong, 2013); also, they stimulate cell differentiation program and induce apoptosis of transformed cells ( Kumano et al., 1985; Yeh et al., 2007; Chong, 2013). Taken together, these results suggest that glucomannan could indirectly promote an environment that is unfavorable for cancer development, at least in the gastroenterological system ( Figure 2). Glucomannan Serves as a Targeted Carrier for Anti-Cancer Drug Delivery Some research has shown that it helps with weight-loss by suppressing or reducing appetite (delays emptying of the stomach) and assisting with more regular bowel movements. Lipozene’s marketing department, not their supplement, deserves flagellation and it is they that are largely responsible for the interest in glucomannan, when the gel caps could be filled with psyllium husk and be equally (in)effective and harmless. Glucomannan Health Benefits There is no evidence to support this and we have to call it urban medical mythology, possibly spurred on by jokes that a person would have to take so much glucomannan to lose weight that they would ‘explode.’

But is this true? Let’s take a look. Here’s the truth behind glucomannan benefits. What is Glucomannan? It can give you diarrhoea: Glucomannan is a ‘bulk-forming laxative’ that is often used as a treatment for constipation. However, take too much of the soluble fibre, and it can be too effective. However, glucomannan hasn’t proved effective for weight loss (any more than any fiber might be), isn’t harmful and doesn’t interest scientists very much. There is also some evidence to suggest that like other soluble sources of fibre it reduces the absorption of proteins and fats, which may further have an impact to overall calorie intake, especially when combined with an energy restricted diet. Glucomannan for Cholesterol Glucomannan could reduce blood pressure: There is some limited evidence to suggest that this could work. However, the jury is still out.Another study involved giving adults 1.3 grams of glucomannan powder before breakfast, lunch, and dinner. After 8 weeks, it did not find any difference between weight loss results in those that took glucomannan and those that took a placebo. Another glucomannan-mediated anti-cancer effect could be ascribed to its role as an antioxidant inducer ( Miadoková et al., 2006; Ansil et al., 2013; Ansil et al., 2014b; Wu et al., 2014). An earlier study confirmed that glucomannan isolated from C. utilis exerts anti-mutagenic function in a mouse model of cyclophosphamide-induced mutagenicity, which may result from the decreased ROS level ( Chorvatovicova et al., 1999). Miadoková et al. further concluded that glucomannan from C. utilis cell wall exerts the anti-oxidative activity through iron chelation and scavenging of hydroxyl radicals in mouse leukemia cell ( Miadoková et al., 2006). In line with the above observation, glucomannan or AKe was demonstrated to enhance the expression of antioxidant enzymes in 1,2-dimethylhydrazine (DMH)-induced colon carcinogenesis and N-nitrosodiethylamine-induced hepatocellular carcinoma in rats ( Ansil et al., 2013; Ansil et al., 2014c). Besides, Konjac glucomannan was able to ameliorate AOM-induced genotoxicity via alleviating the DNA damage process initiated by accumulated ROS ( Wu et al., 2014) ( Figure 1). Type 2 diabetes is a growing problem in western nations, yet is a preventable disease in most cases. It is believed by experts that problems arise in response to sudden spikes in glucose, typically from the consumption of sugary foods and drinks. When these spikes of blood glucose occur repeatedly, the body can start to become resistant to the effects of insulin. One study is Asian, but like much of the other research focuses on the use of glucomannan in animal feed.

This gel-like structure also delays emptying of the stomach, helping us to feel fuller for longer when compared to a standard diet.Glucomannan is a dietary fibre that comes from elephant yam, the root of the konjac plant. It is often sold as a dietary supplement thanks to its possible health benefits, including lowering cholesterol and regulating blood sugar levels. But what’s the link between glucomannan and weight loss? Evidence suggests this fibre can help suppress appetite, promote feelings of fullness, and reduce calorie consumption. However, it will only help as part of a balanced diet and active lifestyle. Finding the Right Weight Loss Method for You Findings showed that all three glucomannan groups had significant weight loss compared to placebo or diet groups. However there was little statistical difference between the three – participants in all three glucomannan groups lost approximately 0.8 kg (1.8 lbs) per week. Just as importantly, however, studies suggest that larger volumes of cholesterol are actually excreted when individuals supplement with glucomannan. One such analysis found that Konjac glucomannan “improved blood lipid levels by enhancing fecal excretion”. Glucomannan for Diabetes Glucomannan can cause bloating: A common complaint of people who start to take glucomannan is that it causes bloating and flatulence. This is normal. It’s a common consequence of introducing lots of fibre into your diet.